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online can make all the difference. https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/556e037f-46e5-41cf-b747-b814ee443658/1M4A.png Grohar Lab Funding https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/7a0764f9-b663-4d7f-9442-799e837b0870/SU2C.png Grohar Lab Funding - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/d9249f08-07d6-4974-9f2b-f5d8520fe769/Screenshot+2024-10-01+at+2.41.39%E2%80%AFPM.png Grohar Lab Funding https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1618325936619-49RCEUXMOI2BAYKE3LAT/Quad-W-Foundation.jpg Grohar Lab Funding https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1618696397486-RNG9R7348OK9NQQVEPTD/AACR+2.jpg Grohar Lab Funding https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1618696248571-B00AKQ0OQ10R2Z6E8W1F/VAI+.png Grohar Lab Funding 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Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1635362400412-8JAMQ97YAX71S436LH6I/inhibrx_Logo.jpg Grohar Lab Funding - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/53b81f35-d2cf-44c2-a35f-931160698930/JAZZ+HEADER-NAV_LOGO-en-us-1641843302301.png Grohar Lab Funding - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1618696136768-RORFDBECW22KEYXASWZZ/Vandy.gif Grohar Lab Funding https://www.groharlab.org/grohar daily 0.75 2025-05-15 https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/58255165-fafa-4ad5-a200-b118bdd51fd6/GROHAR_Patrick4x5.jpg About https://www.groharlab.org/team daily 0.75 2025-07-21 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This makes the clinical translation of our therapies the most important step in the process. We collaborate with expert clinical trialists to develop clinical trials rooted in our preclinical work. The goal of these studies is to test these agents in a rigorous fashion and at the same time gain insight into the fundamental biology of the disease. SARC037 was the realization of this approach. This study was developed in collaboration with national experts in sarcoma. It has provided the basis for future clinical studies of trabectedin and analogs such as lurbinectedin. The LiFFT trial (Lurbinectedin in FET-Fused Tumors) is currently recruiting patients. https://www.groharlab.org/home/discovery monthly 0.5 2026-08-04 https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1618783803405-7GHYPRV05E04VD187ALW/unsplash-image-pwcKF7L4-no.jpg Grohar Lab Homepage - Discovery - Discovery The Grohar lab uses a variety of unbiased screening approaches to identify active compounds and combinations both in our lab and in collaboration with other investigators and biotechnology companies. These studies involve FDA approved compounds as well as novel compounds. More recently, we have focused on the identification of molecular targets that perturb the activity of EWS::FLI1 as a means to better understand the biology of target inhibition and to identify new agents. https://www.groharlab.org/home/mechanistic monthly 0.5 2026-08-04 https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1622224038177-42BV64KWNTB0Q7A8DPQ4/shadowboxmechpharm.png Grohar Lab Homepage - Mechanistic Pharmacology - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.groharlab.org/home/translation monthly 0.5 2026-08-04 https://images.squarespace-cdn.com/content/v1/606c8b9e930a2f43be43647b/1622139923965-U9CN9IHFJJJXUUBQO34K/microCT+trans+web+image.png Grohar Lab Homepage - Translational Studies - Translational Studies A major barrier to therapeutic efficacy is the gap between the bench and the bedside. We spend a considerable amount of effort focused on understanding the molecular pharmacology of target suppression to develop mechanistically informed clinical studies. Correlative biology that supports clinical translation and guides future studies: A key focus of our translational studies is understanding the relationships between drug exposure and target suppression both in vitro and in vivo. In addition, we have worked to develop methods to quantitate target suppression in tissue. Leveraging resources from the SARC037 clinical trial, we have expanded our translational efforts trying to better understand mechanisms of drug sensitivity and resistance using patient tissue collected on our study.