Translational Studies
A major barrier to therapeutic efficacy is the gap between the bench and the bedside. We spend a considerable amount of effort focused on understanding the molecular pharmacology of target suppression to develop mechanistically informed clinical studies.
Correlative biology that supports clinical translation and guides future studies: A key focus of our translational studies is understanding the relationships between drug exposure and target suppression both in vitro and in vivo. In addition, we have worked to develop methods to quantitate target suppression in tissue.
Leveraging resources from the SARC037 clinical trial, we have expanded our translational efforts trying to better understand mechanisms of drug sensitivity and resistance using patient tissue collected on our study.